Evaluation of Uterine Fibroids by Contrast Enhanced Ultrasound (CEUS) and Subharmonic- Aided Pressure Estimation (SHAPE) Pre and Post-Uterine Artery Embolization (UAE)

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

This study goals are to determine the patterns of uterine fibroid vascularity pre and post UAE using CEUS resulting in an alternative to gadolinium-enhanced MRI that is less expensive, has less contra-indications and side effects, is real time, and noninvasive helping physicians to evaluate the result of UAE procedures. Also, this study will evaluate uterine fibroid pressures using SHAPE, comparing the results with normal myometrium tissue in order to determine its characteristics and tissue differences, which we believe will lead to the development of a new biomarker for the diagnosis and treatment of uterine fibroids.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: f
View:

• Be a female diagnosed with endometrial cancer and scheduled for UAE.

• Be over the age of 18 years.

• If the subject is of child-bearing potential, must have a negative pregnancy test.

• Be conscious and able to comply with study procedures.

• Have read and signed the IRB approved consent form for participating in the study.

Locations
United States
Pennsylvania
Thomas Jefferson University
RECRUITING
Philadelphia
Contact Information
Primary
Priscilla Machado, MD
priscilla.machado@jefferson.edu
215-955-4279
Time Frame
Start Date: 2025-01-27
Estimated Completion Date: 2026-09-30
Participants
Target number of participants: 80
Treatments
Experimental: Uterine fibroids
Related Therapeutic Areas
Sponsors
Leads: Thomas Jefferson University

This content was sourced from clinicaltrials.gov